Del(3Adh7-Adh5)1Gdu
Targeted Allele Detail

Summary

• Symbol: Del(3Adh7-Adh5)1Gdu
• Name: deletion, Chr 3, Gregg Duester 1
• MGI ID: MGI:6280954
• Synonyms: Adh-del
• Gene: Del(3Adh7-Adh5)1Gdu Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(3Adh7-Adh5)1Gdu involves 6 genes/genome features (Adh7, Adh1, Adh6a ...) View all
• Mutation details: A double targeting strategy is used to remove a 250 kb region that includes the six alcohol dehydrogenase genes. One targeting construct was designed to insert a loxP site and hygromycin resistance gene into intron 3 the Adh7 gene, a second targeting construct was designed to insert a neomycin resistance gene and loxP site into intron 4 of the Adh5 gene. All six Adh genes are located on Chr3 in the following order: Adh7, Adh1, Adh6a, Adh6b, Adh4, Adh5; no other genes are located in this region. Cre-mediated recombination removed the floxed region and the neomycin and hygromycin cassetes. (J:271228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(3Adh7-Adh5)1Gdu Mutation: 0 strains or lines available

References

• Original: J:271228 Kumar S, et al., Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models. Biochim Biophys Acta. 2012 Jan;1821(1):198-205
• All: 1 reference(s)