Gt(ROSA)26Sor^{tm1(GNA11*Q209L)Ychen}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(GNA11*Q209L)Ychen}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Yu Chen
• MGI ID: MGI:6280499
• Synonyms: R26-LSL-GNA11^Q209L
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(GNA11*Q209L)Ychen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271104
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(GNA11*Q209L)Ychen} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GNA11 (2767)

  Gna11

  (MGI:95766)

• Mutation details: The targeting construct inserted into the locus a loxP flanked neomycin/STOP cassette and human GNA11 cDNA with a glutamine to leucine substitution at amino acid 209 (Q209L). Upon cre-mediated recombination of the loxP, the neo-STOP cassette is excised and the mutant is expressed. (J:271104)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:271104 Moore AR, et al., GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. Cell Rep. 2018 Feb 27;22(9):2455-2468
• All: 1 reference(s)