Phf6^em2Azbi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Phf6^em2Azbi
• Name: PHD finger protein 6; endonuclease-mediated mutation 2, Azad Bonni
• MGI ID: MGI:6280443
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^em2Azbi page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology generated a 1 bp insertion (G) at nucleotide 298 resulting in a frameshift mutation. Detailed molecular characterization confirmed this is a null allele. (J:271089)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 10 strains or lines available

References

• Original: J:271089 Cheng C, et al., Characterization of a Mouse Model of Borjeson-Forssman-Lehmann Syndrome. Cell Rep. 2018 Nov 6;25(6):1404-1414.e6
• All: 1 reference(s)