Mir33^em1Cfh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir33^em1Cfh
• Name: microRNA 33; endonuclease-mediated mutation 1, Carlos Fernandez-Hernando
• MGI ID: MGI:6280346
• Synonyms: miR-33^-
• Gene: Mir33 Location: Chr15:82082323-82082391 bp, + strand Genetic Position: Chr15, 38.54 cM
• Alliance: Mir33^em1Cfh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated excision of Mir33 was accomplished using targeted guide sequences toward intron 16 of the Srebf2 gene. (J:271060)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir33 Mutation: 1 strain or line available

References

• Original: J:271060 Price NL, et al., Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance. Cell Rep. 2018 Feb 20;22(8):2133-2145
• All: 2 reference(s)