Tek^tm1.1Aug
Targeted Allele Detail

Summary

• Symbol: Tek^tm1.1Aug
• Name: TEK receptor tyrosine kinase; targeted mutation 1.1, Hellmut Augustin
• MGI ID: MGI:6279997
• Synonyms: Tie2^flox
• Gene: Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
• Alliance: Tek^tm1.1Aug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250996
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector containing two loxP sites flanking exon1 of Tek2 (Tie2) and a part of its promoter region; and a FRT flanked neomycin selection cassette was used for homologous recomibination. The neomycin cassette was excised by crossing mice with FLP deleter mice. (J:250996)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tek Mutation: 90 strains or lines available

References

• Original: J:250996 Savant S, et al., The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep. 2015 Sep 22;12(11):1761-73
• All: 10 reference(s)