Sh3rf2^tm1Zhxu
Targeted Allele Detail

Summary

• Symbol: Sh3rf2^tm1Zhxu
• Name: SH3 domain containing ring finger 2; targeted mutation 1, Zhiheng Xu
• MGI ID: MGI:6279851
• Gene: Sh3rf2 Location: Chr18:42186732-42292025 bp, + strand Genetic Position: Chr18, 22.21 cM
• Alliance: Sh3rf2^tm1Zhxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced by a lacZ expression cassette and a FRT-flanked neomycin resistance gene. (J:270945)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3rf2 Mutation: 53 strains or lines available

References

• Original: J:270945 Wang S, et al., Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development Deficits and Autistic-Like Behaviors in Mice. Cell Rep. 2018 Dec 11;25(11):2963-2971.e6
• All: 1 reference(s)