Gps2^tm1.1Etr
Targeted Allele Detail

Summary

• Symbol: Gps2^tm1.1Etr
• Name: G protein pathway suppressor 2; targeted mutation 1.1, Eckardt Treuter
• MGI ID: MGI:6279816
• Synonyms: Gps2^flox
• Gene: Gps2 Location: Chr11:69804714-69807417 bp, + strand Genetic Position: Chr11, 42.92 cM
• Alliance: Gps2^tm1.1Etr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239857
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a FRT-flanked neomycin cassette followed by a second loxP site were inserted between exons 5 and 6. Flp-mediated recombination removed the selection cassette, leaving exons 2-5 floxed. (J:239857)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gps2 Mutation: 21 strains or lines available

References

• Original: J:239857 Fan R, et al., Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nat Med. 2016 Jul;22(7):780-91
• All: 5 reference(s)