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Atp2b1Tg(Thy1-CHMP2B*)1Rene
Transgenic Allele Detail
Nomenclature
Symbol: Atp2b1Tg(Thy1-CHMP2B*)1Rene
Name: ATPase, Ca++ transporting, plasma membrane 1; transgene insertion 1, Frederique Rene
MGI ID: MGI:6278934
Synonyms: CHMP2Bintron5
Gene: Atp2b1  Location: Chr10:98914630-99026143 bp, + strand  Genetic Position: Chr10, 50.97 cM, cytoband C3
Transgene
origin
Strain of Origin:  (FVB/N x (C57BL/6J x DBA/2J))F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Atp2b1Tg(Thy1-CHMP2B*)1Rene expresses 1 gene
 
Mutation detailsThe human CHMP2B cDNA containing a missense mutation in the splice acceptor site of exon 6 that is a mutation identified in human familial FTD, and tagged with two hemagglutinin sequences, is under the control of the mouse Thy1.2 promoter. The transgene integrated within chromosome 10: 98950250-98968278 in the Atp1b1 gene within the large first intron. Atp2b1 mRNA levels are not modified although a trend of a decrease is seen in homozygous mice. One line was established. (J:237873)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp2b1 Mutation:  13 strains or lines available
References
Original:  J:237873 Vernay A, et al., A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia. Hum Mol Genet. 2016 Aug 01;25(15):3341-3360
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory