Gadd45a^em1Ahoke
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gadd45a^em1Ahoke
• Name: growth arrest and DNA-damage-inducible 45 alpha; endonuclease-mediated mutation 1, Ahmet Hoke
• MGI ID: MGI:6278001
• Synonyms: Gadd45a^flox
• Gene: Gadd45a Location: Chr6:67012080-67014391 bp, - strand Genetic Position: Chr6, 30.72 cM
• Alliance: Gadd45a^em1Ahoke page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing was used to insert loxP sites flanking the first three coding exons of the gene. In addition, a V5 epitope tag was placed directly after the start codon. (J:313424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gadd45a Mutation: 15 strains or lines available

References

• Original: J:313424 Ehmsen JT, et al., GADD45A is a protective modifier of neurogenic skeletal muscle atrophy. JCI Insight. 2021 Jul 8;6(13)
• All: 1 reference(s)