Nrg3^tm1Cbm
Targeted Allele Detail

Summary

• Symbol: Nrg3^tm1Cbm
• Name: neuregulin 3; targeted mutation 1, Carmen Birchmeier
• MGI ID: MGI:6277992
• Gene: Nrg3 Location: Chr14:38090909-39195045 bp, - strand Genetic Position: Chr14, 22.18 cM, cytoband B
• Alliance: Nrg3^tm1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270200
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin cassette replaced exon 2 of the gene, which encodes the N-terminal part of the epidermal growth factor-like domain in the encoded protein. Deletion of exon 2 introduces a frameshift mutation in the truncated transcript. Western blot analysis of brain lysates showed that no detectable encoded protein was present in homozygous mice. (J:270200)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg3 Mutation: 56 strains or lines available

References

• Original: J:270200 Loos M, et al., Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. Biol Psychiatry. 2014 Oct 15;76(8):648-55
• All: 2 reference(s)