Tg(LCR-HBG2,-HBG1)1352Hhb
Transgene Detail

Summary

• Symbol: Tg(LCR-HBG2,-HBG1)1352Hhb
• Name: transgene insertion 1352, Henny Billett
• MGI ID: MGI:6277094
• Synonyms: LCR ^Ggamma ^Agamma psi beta
• Transgene: Tg(LCR-HBG2,-HBG1)1352Hhb Location: unknown
• Alliance: Tg(LCR-HBG2,-HBG1)1352Hhb page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human beta globin cluster is modified such that the locus control region (LCR) consisting of 4 DNAse I hypersensitive site (HS4-1) is inserted upstream of HBG2, HBG1, and the HBBP1 pseudogene. Founder line 1352 was established. Expression of the HBG2 gene is 3-7 fold higher than the HBG1 gene in embryonic and fetal erythroid cells. (J:39123)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:39123 Arcasoy MO, et al., High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. Mol Cell Biol. 1997 Apr;17(4):2076-89
• All: 2 reference(s)