Pik3c2a^tm1.1Ytak
Targeted Allele Detail

Summary

• Symbol: Pik3c2a^tm1.1Ytak
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; targeted mutation 1.1, Yoh Takuwa
• MGI ID: MGI:6276294
• Synonyms: C2alpha^flox
• Gene: Pik3c2a Location: Chr7:115936500-116042684 bp, - strand Genetic Position: Chr7, 61.62 cM
• Alliance: Pik3c2a^tm1.1Ytak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247494
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette and left exon 1 floxed. (J:247494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c2a Mutation: 100 strains or lines available

References

• Original: J:247494 Yoshioka K, et al., Endothelial PI3K-C2alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med. 2012 Oct;18(10):1560-9
• All: 2 reference(s)