Tg(CAG-SLC31A1)#Pejc
Transgene Detail

Summary

• Symbol: Tg(CAG-SLC31A1)#Pejc
• Name: transgene insertion, Peter J Crouch
• MGI ID: MGI:6276258
• Synonyms: hCTR1
• Transgene: Tg(CAG-SLC31A1)#Pejc Location: unknown
• Alliance: Tg(CAG-SLC31A1)#Pejc page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-SLC31A1)#Pejc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SLC31A1 (1317)

  Slc31a1

  (MGI:1333843)

  human cDNA with N-terminal Flag tag sequence

• Mutation details: The coding sequence of the human cDNA was fused at the 5' end to Flag epitope tag sequence and inserted between the CAG promoter and poly(A) signal sequences. The resulting transgene construct was micro-injected into pronuclei of C57BL/6 oocytes. Expression was confirmed by qRT-PCR. (J:270069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:270069 Roberts BR, et al., Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci. 2014 Jun 4;34(23):8021-31
• All: 2 reference(s)