Brd1^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Brd1^tm1.2Arte
• Name: bromodomain containing 1; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:6276007
• Synonyms: Brd^{1tm1569.2Arte}
• Gene: Brd1 Location: Chr15:88571237-88618436 bp, - strand Genetic Position: Chr15, 44.17 cM
• Alliance: Brd1^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a FRT site flanked neomycin resistance cassette were inserted into intron 2 and a second loxP site into intron 5. The neo cassette was removed through subsequent flp-mediated recombination. Exons 3-5 were deleted through subsequent cre-mediated recombination. (J:269898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brd1 Mutation: 119 strains or lines available

References

• Original: J:269898 Qvist P, et al., The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice. Biol Psychiatry. 2017 Jul 1;82(1):62-76
• All: 6 reference(s)