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Targeted Allele Detail
Symbol: Lgi1tm2.1Jkc
Name: leucine-rich repeat LGI family, member 1; targeted mutation 2.1, John K Cowell
MGI ID: MGI:6275636
Synonyms: LGI1 cKO, LGI1flox
Gene: Lgi1  Location: Chr19:38264782-38308939 bp, + strand  Genetic Position: Chr19, 32.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:269784
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting vector is designed to insert a loxP site upstream of exon 3, and an FRT-flanked neomycin selection cassette followed by a second loxP site downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 thorugh 4 floxed. (J:269784)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lgi1 Mutation:  8 strains or lines available
Original:  J:269784 Silva J, et al., Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice. Genesis. 2018 Nov 29;:e23268
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory