Tg(Pcp2-Cbln4)#Jim
Transgene Detail
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Symbol: |
Tg(Pcp2-Cbln4)#Jim |
Name: |
transgene insertion, James I Morgan |
MGI ID: |
MGI:6275226 |
Synonyms: |
L7-Cbln4 |
Transgene: |
Tg(Pcp2-Cbln4)#Jim Location: unknown
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Alliance: |
Tg(Pcp2-Cbln4)#Jim page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Pcp2-Cbln4)#Jim expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Cbln4 (MGI:2154433) |
mouse wild-type cDNA |
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Mutation details: In the transgene construct the mouse cerebellin 4 precursor protein cDNA was inserted into a unique BamHI site in exon 4 of the mouse Purkinje cell protein 2 (L7) gene that had its ATG start site inactivated, thus placing the inserted gene effectively under control of the promoter of the host gene without expressing the host peptide. The copy number is estimated by qPCR to be around 22.
(J:269669)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:269669 Rong Y, et al., Glycosylation of Cblns attenuates their receptor binding. Brain Res. 2018 Sep 1;1694:129-139 |
All: |
1 reference(s) |
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