Tg(CAG-IL1A)#Takm
Transgene Detail

Summary

• Symbol: Tg(CAG-IL1A)#Takm
• Name: transgene insertion, Takeshi Miyamoto
• MGI ID: MGI:6274747
• Synonyms: hIL-1 cTg
• Transgene: Tg(CAG-IL1A)#Takm Location: unknown
• Alliance: Tg(CAG-IL1A)#Takm page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene construct that was micro-injected into fertilized eggs conatins the following elements: the CAG promoter-enhancer, a loxP site flanked neomycin resistance gene cassette (which includes p(A) sequences), and the human interleukin 1 alpha gene. This creates a conditional-ready allele where the human gene is only expressed after the deletion of the neo cassette through cre-mediated recombination. (J:269353)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:269353 Oike T, et al., IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse. Sci Rep. 2018 Oct 25;8(1):15783
• All: 1 reference(s)