Plcg2^em1Bwef
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plcg2^em1Bwef
• Name: phospholipase C, gamma 2; endonuclease-mediated mutation 1, Benedikt Wefers
• MGI ID: MGI:6274477
• Synonyms: Plcg2^{em1(P522R)Bwef}, Plcg2(P522R), Plcg2 p.P522R
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^em1Bwef page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9-mediated homologous recombination using a synthetic oligodeoxynucleotide created a nucleotide substitution (CCC to AGG) in exon 17 of Plcg2 that results in the amino acid substitution P522R. One additional silent nucleotide exchange within the protospacer region created a StuI restriction site for genotyping purposes. (J:307714)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 73 strains or lines available

References

• Original: J:307714 Takalo M, et al., The Alzheimer's disease-associated protective Plcgamma2-P522R variant promotes immune functions. Mol Neurodegener. Sep 11;15(1):52
• All: 1 reference(s)