Tg(CST3*L68Q)#Efl
Transgene Detail

Summary

• Symbol: Tg(CST3*L68Q)#Efl
• Name: transgene insertion, Efrat Levy
• MGI ID: MGI:6273895
• Synonyms: CysC-V
• Transgene: Tg(CST3*L68Q)#Efl Location: unknown
• Alliance: Tg(CST3*L68Q)#Efl page

Transgene origin

• Strain of Origin: Swiss Webster

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CST3*L68Q)#Efl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CST3 (1471)

  Cst3	(MGI:102519)

  human gene encoding L68Q mutation

• Mutation details: An 8.9 kb genomic fragment containing the human gene was micro-injected into single-cell embryos. This version of the gene contains a T>A mutation causing a p.Leu68Gln substitution in the encoded peptide. This mutation is found in patients suffering from hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I). (J:269038)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:269038 Pawlik M, et al., Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. J Mol Neurosci. 2004;22(1-2):13-8
• All: 1 reference(s)