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Spontaneous Allele Detail
Symbol: Mir16-1m1
Name: microRNA 16-1; mutation 1
MGI ID: MGI:6273332
Gene: Mir16-1  Location: Chr14:61869329-61869421 bp, - strand  Genetic Position: Chr14, 33.16 cM
Strain of Origin:  NZB/BlNJ
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Single point mutation
Mutation detailsA point mutation in the 3' DNA adjacent to pre-mir-16-1 region in NZB. A T-to-A mutation at base 61,631,880 (GRCm38) on the sense strand of chr 14 in the NZB/BlNJ strain is not present in DBA/2J, C57BL/6J, SJL/J, NZW, BALB/c, and NOD/SCID. Levels of miR-16 were decreased in NZB lymphoid tissue. (J:124364)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir16-1 Mutation:  4 strains or lines available
Original:  J:124364 Raveche ES, et al., Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood. 2007 Jun 15;109(12):5079-86
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory