Wdfy4^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Wdfy4^tm1.1Nju
• Name: WD repeat and FYVE domain containing 4; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6273252
• Synonyms: Wdfy4^flox
• Gene: Wdfy4 Location: Chr14:32681504-32907465 bp, - strand Genetic Position: Chr14, 19.44 cM
• Alliance: Wdfy4^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and a FRT-neomycin-FRT-loxP cassette was inserted into intron 2. Flp-mediated recombination removed the neomycin gene leaving exon 3 floxed. (J:267228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdfy4 Mutation: 142 strains or lines available

References

• Original: J:267228 Yuan Q, et al., WDFY4 Is Involved in Symptoms of Systemic Lupus Erythematosus by Modulating B Cell Fate via Noncanonical Autophagy. J Immunol. 2018 Nov 1;201(9):2570-2578
• All: 2 reference(s)