Sgce^tm1.1Rogo
Targeted Allele Detail

Summary

• Symbol: Sgce^tm1.1Rogo
• Name: sarcoglycan, epsilon; targeted mutation 1.1, Rose E Goodchild
• MGI ID: MGI:6272740
• Synonyms: Sgce^ex5flox
• Gene: Sgce Location: Chr6:4674350-4747180 bp, - strand Genetic Position: Chr6, 1.81 cM
• Alliance: Sgce^tm1.1Rogo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268582
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 5. The neo cassette was deleted through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 5 floxed. (J:268582)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgce Mutation: 46 strains or lines available

References

• Original: J:268582 Maltese M, et al., Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition. Neurobiol Dis. 2017 Dec;108:128-139
• All: 1 reference(s)