Cyp2g1^tm2Ding
Targeted Allele Detail

Summary

• Symbol: Cyp2g1^tm2Ding
• Name: cytochrome P450, family 2, subfamily g, polypeptide 1; targeted mutation 2, Xinxin Ding
• MGI ID: MGI:6272645
• Synonyms: Cyp2g1-null
• Gene: Cyp2g1 Location: Chr7:26508352-26520622 bp, + strand Genetic Position: Chr7, 15.5 cM, cytoband A3
• Alliance: Cyp2g1^tm2Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268320
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was deleted through subsequent cre-mediated recombination. This creates a null allele lacking exon 3. RT-PCR confirmed the lack of transcript expression. (J:268320)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2g1 Mutation: 30 strains or lines available

References

• Original: J:268320 Zhou X, et al., A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. Mol Pharmacol. 2011 Apr;79(4):710-23
• All: 1 reference(s)