Fbxo38^em1Chx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxo38^em1Chx
• Name: F-box protein 38; endonuclease-mediated mutation 1, Chenqi Xu
• MGI ID: MGI:6272381
• Synonyms: Fbxo38^flox
• Gene: Fbxo38 Location: Chr18:62637226-62681766 bp, - strand Genetic Position: Chr18, 35.11 cM
• Alliance: Fbxo38^em1Chx page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was targeted using CRISPR/Cas9 technology with sgRNAs and a targeting vector. The resulting allele contains loxP sites in introns 2 and 3, creating a conditional-ready allele with exon 3 floxed. (J:268229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo38 Mutation: 50 strains or lines available

References

• Original: J:268229 Meng X, et al., FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 2018 Dec;564(7734):130-135
• All: 1 reference(s)