Notch1^tm7.1Rko
Targeted Allele Detail

Summary

• Symbol: Notch1^tm7.1Rko
• Name: notch 1; targeted mutation 7.1, Raphael Kopan
• MGI ID: MGI:6272371
• Synonyms: N1V-KI
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm7.1Rko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A gene encoding green fluorescence Venus protein and floxed PGK-neo cassette was inserted into mouse gene to fuse the Venus at most C terminus of the encoded protein. Heterozygous knock-in mice were crossed with CAG-Cre mice to excise PGK-neo cassette region. (J:254461)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 116 strains or lines available

Notes

Homozygous mice are viable and fertile with no observed gross developmental defects.

References

• Original: J:254461 Hayashi Y, et al., A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Sci Rep. 2016 Apr 4;6:23969
• All: 1 reference(s)