Tg(Tlr4)394Dmal
Transgene Detail

Summary

• Symbol: Tg(Tlr4)394Dmal
• Name: transgene insertion 394, Danielle Malo
• MGI ID: MGI:6272360
• Transgene: Tg(Tlr4)394Dmal Location: unknown
• Alliance: Tg(Tlr4)394Dmal page

Transgene origin

• Strain of Origin: (C3H/HeNHsd x C57BL/6NHsd)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tlr4)394Dmal expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tlr4 (MGI:96824)

• Mutation details: This transgene was generated from BAC 152C16 (from 129 mice). Lines 382, 388, 390, and 394 were generated with only line 382 containing the SP6 and promoter the microsatellite amplification polymorphism, which is bigger in 129 mice than in C3H and C57BL/6J strains and is absent from C57BL/10NCR). (J:83713)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83713 Bihl F, et al., Overexpression of toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. J Immunol. 2003 Jun 15;170(12):6141-50
• All: 1 reference(s)