Il23r^tm1.2Jusc
Targeted Allele Detail

Summary

• Symbol: Il23r^tm1.2Jusc
• Name: interleukin 23 receptor; targeted mutation 1.2, Jurgen Scheller
• MGI ID: MGI:6272274
• Synonyms: IL-23R-Y416FdeltaICD
• Gene: Il23r Location: Chr6:67399916-67468839 bp, - strand Genetic Position: Chr6, 30.85 cM
• Alliance: Il23r^tm1.2Jusc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268135
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: Exon 10 was replaced with one containing a point mutation resulting in a tyrosine to phenylalanine change at amino acid 416 (Y416F) and exon 11 was flanked by loxP sites. In addition, a neomycin resistance cassette flanked by FRT sites was inserted upstream of exon 11. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination deleted exon 11 and abrogates STAT and ERK signaling and leads to a shortened intracellular domain with 14 alternative amino acids coded by the former intron 11 until translation is stopped by a new stop codon. (J:268135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23r Mutation: 71 strains or lines available

References

• Original: J:268135 Engelowski E, et al., IL-23R Signaling Plays No Role in Myocardial Infarction. Sci Rep. 2018 Nov 20;8(1):17078
• All: 1 reference(s)