Asxl1^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Asxl1^{tm1e(EUCOMM)Wtsi}
• Name: ASXL transcriptional regulator 1; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:6272013
• Gene: Asxl1 Location: Chr2:153187750-153245927 bp, + strand Genetic Position: Chr2, 75.41 cM
• Alliance: Asxl1^{tm1e(EUCOMM)Wtsi} page
• IMPC: Asxl1 gene page

Mutation origin

• Mutant Cell Line: EPD0080_1_B11
• Germline Transmission: Earliest citation of germline transmission: J:253719
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt2

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asxl1 Mutation: 116 strains or lines available

References

• Original: J:253719 Youn HS, et al., Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation. Sci Rep. 2017 Jul 12;7(1):5198
• All: 1 reference(s)