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Tg(Camk2a-Polg*D181A)BTkato
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-Polg*D181A)BTkato
Name: transgene insertion B, Tadafumi Kato
MGI ID: MGI:6270168
Transgene: Tg(Camk2a-Polg*D181A)BTkato  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Camk2a-Polg*D181A)BTkato expresses 1 gene
 
Mutation detailsThe mouse Polg cDNA in which an aspartate residue at position 181 was replaced with an alanine is under the control of the mouse calcium/calmodulin-activated protein kinase II alpha promoter. Three lines (A, B, and C) were generated. Line B is the high mRNA expressing line. RT-PCR confirmed expression of mRNA that is as abundant as the endogenous wild-type mRNA in most parts of the forebrain and mutant expression is nearly restricted in the brain. (J:127895)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127895 Kasahara T, et al., Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol Psychiatry. 2006 Jun;11(6):577-93, 523
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory