Insm1^tm2.1Jga
Targeted Allele Detail

Summary

• Symbol: Insm1^tm2.1Jga
• Name: insulinoma-associated 1; targeted mutation 2.1, Jaime Garcia-Anoveros
• MGI ID: MGI:6269454
• Synonyms: Insm1^F
• Gene: Insm1 Location: Chr2:146064021-146066940 bp, + strand Genetic Position: Chr2, 71.33 cM
• Alliance: Insm1^tm2.1Jga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267715
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using BAC clone RP22-439G2, a loxP site was inserted upstream of the Kozak sequence in the 5' UTR and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted in the 3' UTR. Subsequent flp-mediated recombination removed the neo cassette, leaving a conditional-ready allele with the single-exon coding region floxed. (J:267715)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Insm1 Mutation: 13 strains or lines available

References

• Original: J:267715 Wiwatpanit T, et al., Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1. Nature. 2018 Nov;563(7733):691-695
• All: 4 reference(s)