Il12a^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Il12a^m1Btlr
• Name: interleukin 12a; mutation 1, Bruce Beutler
• MGI ID: MGI:6269359
• Synonyms: bakers_dozen
• Gene: Il12a Location: Chr3:68597977-68605880 bp, + strand Genetic Position: Chr3, 31.92 cM
• Alliance: Il12a^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced TCAC>TC substitution at base pair 68,697,987 (v38) on chromosome 3, or base pair 7,344 in the GenBank genomic region NC_000069 within exon 8 out of 8 total exons. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in a frame-shift in the encoded protein. The frame-shift is predicted to result in coding of 34 aberrant amino acids after amino acid 216, and is predicted to result in loss of the original stop codon after amino acid 236. The frame-shift results in coding of a stop codon 45-base pairs within the 3-untranslated region (3-UTR) of exon 8. (J:267667)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il12a Mutation: 33 strains or lines available

References

• Original: J:267667 Zhang D, et al., Mutagenetix entry for bakers_dozen. MGI Direct Data Submission. 2018
• All: 1 reference(s)