Tg(TG-cre/ERT2)248Ubc
Transgene Detail

Summary

• Symbol: Tg(TG-cre/ERT2)248Ubc
• Name: transgene insertion 248, Uppsala University
• MGI ID: MGI:6267050
• Synonyms: TGcreER^T2, TG-Cre-ERT2 #248, Tg(Tg-cre/ERT2)248
• Transgene: Tg(TG-cre/ERT2)248Ubc Location: unknown
• Alliance: Tg(TG-cre/ERT2)248Ubc page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(TG-cre/ERT2)248Ubc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	TG (280706)

• Mutation details: This transgene contains a 2-kb bovine thyroglobulin promoter sequence driving expression of Cre recombinase fused to a modified ligand-binding domain (LBD) of the human estrogen receptor that binds and thus is induced by tamoxifen or 4-hydroxytamoxifen, but not estrogen. Reverse transcription-polymerase chain reaction (RT-PCR) analysis amplified a cre/ERT2 fragment from thyroid tissue of two transgenic founder mice, designated F248 and F300. Northern blot analysis confirmed transgene expression in the thyroid glands, but not in other analyzed tissues, of transgenic mice. (J:267412)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	TG (cattle) Summary of all recombinase alleles driven by TG.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:267412 Roswall P, Taking pressure of anaplastic thyroid carcinoma: Molecular studies of apoptosis and interstitial hypertension (Doctoral dissertation). PhD Thesis - Uppsala University. 2006
• All: 1 reference(s)