Slc9a1^tm1.1Ges
Targeted Allele Detail

Summary

• Symbol: Slc9a1^tm1.1Ges
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1; targeted mutation 1.1, Gary E Shull
• MGI ID: MGI:6267025
• Synonyms: Nhe1^f
• Gene: Slc9a1 Location: Chr4:133097022-133151013 bp, + strand Genetic Position: Chr4, 66.25 cM, cytoband D3-E
• Alliance: Slc9a1^tm1.1Ges page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252857
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by loxP sites. A neomycin-resistant gene flanked by two FRT sites was inserted next to the 5'-loxP site. Flp-mediated recombination removed the neo cassette leaving exon 5 floxed. (J:252857)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a1 Mutation: 43 strains or lines available

References

• Original: J:252857 Begum G, et al., Selective knockout of astrocytic Na(+) /H(+) exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia. 2018 Jan;66(1):126-144
• All: 6 reference(s)