Gria1^tm1.1Thay
Targeted Allele Detail

Summary

• Symbol: Gria1^tm1.1Thay
• Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 1.1, Takashi Hayashi
• MGI ID: MGI:6266854
• Synonyms: CS
• Gene: Gria1 Location: Chr11:56902342-57221070 bp, + strand Genetic Position: Chr11, 34.51 cM
• Alliance: Gria1^tm1.1Thay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267285
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 16 was replaced with one in which the palmitoylation site at cysteine 811 is mutated to serine (C811S). In addition, a silent NruI site mutation was introduced just after the serine mutation site to distinguish the mutant allele. A loxP-flanked PGK-neomycin resistant cassette was inserted at intron 15. Cre-mediated recombination removed the selection cassette. (J:267285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria1 Mutation: 66 strains or lines available

References

• Original: J:267285 Itoh M, et al., Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility. J Neurosci. 2018 Nov 21;38(47):10220-10235
• All: 2 reference(s)