Cebpb^tm1.1Nord
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1.1Nord
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1.1, Magnus Nord
• MGI ID: MGI:6260173
• Synonyms: Cebpb^fl
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1.1Nord page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267247
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This conditional allele was derived from Cebpb^tm1Nord, in which a FRT site-flanked neomycin resistance cassette followed by a loxP site was inserted upstream and a single loxP site downstream of the CCAAT/enhancer binding protein (C/EBP), beta (Cebpb) gene, by Flp recombinase-mediated excision of the selection cassette. (J:267247)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 26 strains or lines available

References

• Original: J:267247 Didon L, et al., Lung epithelial CCAAT/enhancer-binding protein-beta is necessary for the integrity of inflammatory responses to cigarette smoke. Am J Respir Crit Care Med. 2011 Jul 15;184(2):233-42
• All: 1 reference(s)