Asap3^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Asap3^tm1Smoc
• Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6259097
• Synonyms: ASAP3^loxP
• Gene: Asap3 Location: Chr4:135933676-135972527 bp, + strand Genetic Position: Chr4, 68.34 cM
• Alliance: Asap3^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262460
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 5. Deletion of exon 5 is predicted to disrupt partially the BAR domain (including dimerization residues) and other regions including the PH, ArfGAP and ANK domains. (J:262460)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asap3 Mutation: 45 strains or lines available

References

• Original: J:262460 Qian J, et al., ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. Signal Transduct Target Ther. 2017;2:17003
• All: 1 reference(s)