Del(7Peg3-Usp29)1Jkim
Targeted Allele Detail

Summary

• Symbol: Del(7Peg3-Usp29)1Jkim
• Name: deletion, Chr 7, Joomyeong Kim 1
• MGI ID: MGI:6258911
• Synonyms: Peg3-DMR KO, Peg3^KO2
• Gene: Del(7Peg3-Usp29)1Jkim Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259918
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(7Peg3-Usp29)1Jkim involves 2 genes/genome features (Peg3, Usp29) View all
• Mutation details: This allele was created by crossing mice carrying the Usp29^tm1Jkim allele with cre-expressing mice (Tg(Zp3-cre)93Knw). Usp29^tm1Jkim was created as follows: a loxP site was inserted into intron 1 of Peg3 upstream of the Peg3-DMR (differentially methylated region). A neomycin resistance gene cassette (in the same transcriptional direction as the targeted gene) and a second loxP site were inserted into intron 1 of downstream neigbor Usp29, with which Peg3 shares a bidirectional promoter. Cre-mediated recombination deletes the ~4 kb Peg3-DMR region including the first exons of Peg3 and Usp29. (J:259918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(7Peg3-Usp29)1Jkim Mutation: 0 strains or lines available

References

• Original: J:259918 He H, et al., Parental and sexual conflicts over the Peg3 imprinted domain. Sci Rep. 2016 Nov 30;6:38136
• All: 4 reference(s)