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Targeted Allele Detail
Symbol: Crbntm1.1Ble
Name: cereblon; targeted mutation 1.1, Benjamin L Ebert
MGI ID: MGI:6258757
Synonyms: CrbnI391V
Gene: Crbn  Location: Chr6:106780201-106800077 bp, - strand  Genetic Position: Chr6, 49.24 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:267091
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
Mutation detailsThe targeting vector contains an FRT- and loxP-flanked neomycin cassette inserted upstream of exon 11 followed by a point mutation substitution isoleucine for the corresponding human residue, valine (I391V) in exon 11. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:267091)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crbn Mutation:  4 strains or lines available
Original:  J:267091 Fink EC, et al., Crbn (I391V) is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice. Blood. 2018 Oct 4;132(14):1535-1544
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory