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Targeted Allele Detail
Symbol: Adarb2tm1b(KOMP)Mbp
Name: adenosine deaminase, RNA-specific, B2; targeted mutation 1b, Mouse Biology Program, UCDavis
MGI ID: MGI:6257878
Synonyms: Adar3exon3
Gene: Adarb2  Location: Chr13:8202866-8768747 bp, + strand  Genetic Position: Chr13, 3.48 cM, cytoband A1
Mutant Cell Lines:  DEPD0006_14_A03, DEPD0006_14_A05
Germline Transmission:  Earliest citation of germline transmission: J:264218
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 8569208 of Chromosome 13 upstream of the critical exon 3 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 8570796. The critical exon 3 is thus flanked by loxP sites. Cre expression without flp expression created a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:264218)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adarb2 Mutation:  42 strains or lines available
Original:  J:264218 Mladenova D, et al., Adar3 Is Involved in Learning and Memory in Mice. Front Neurosci. 2018;12:243
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory