Hapstr1^{em1(IMPC)Wtsi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hapstr1^{em1(IMPC)Wtsi}
• Name: HUWE1 associated protein modifying stress responses; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6257645
• Gene: Hapstr1 Location: Chr16:8647964-8676786 bp, + strand Genetic Position: Chr16, 4.37 cM, cytoband A3
• Alliance: Hapstr1^{em1(IMPC)Wtsi} page
• IMPC: Hapstr1 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Wellcome Sanger Institute using Cas9 and guides with spacer sequences AACCATGAAAATGGGTCCAC, ACATTGGCAGCCCATTTGAA, ACCTTGGTTAACATATAAAA, and ATGCTCATAATAGTTCACCT that targeted exon(s) ENSMUSE00000286087.4. This resulted in deletion(s) of 88 bp (location: Chr16:8660738-8660825; GRCm39), 456 bp (location: Chr16:8660831-8661286; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hapstr1 Mutation: 38 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)