C2cd3^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: C2cd3^em1(IMPC)Tcp
• Name: C2 calcium-dependent domain containing 3; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:6257547
• Gene: C2cd3 Location: Chr7:100021440-100119359 bp, + strand Genetic Position: Chr7, 54.35 cM
• Alliance: C2cd3^em1(IMPC)Tcp page
• IMPC: C2cd3 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project TCPR1071 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of AGCACCCTGACAGTTACATT and ATGCAGTGTGATGAATACTG targeting the 5' side and CAGCATGAGAACCGTGGGAG targeting the 3' side of a critical exon. This resulted in a 1062-bp deletion Chr7:100389398 to 100390459 (GRCm38). (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any C2cd3 Mutation: 101 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)