Daxx^tm2.1Led
Targeted Allele Detail

Summary

• Symbol: Daxx^tm2.1Led
• Name: Fas death domain-associated protein; targeted mutation 2.1, Philip Leder
• MGI ID: MGI:6256965
• Synonyms: Daxx^delta3, Daxx^Δ3
• Gene: Daxx Location: Chr17:34128388-34134564 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Daxx^tm2.1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266012
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT site flanked targeting vector, with a loxP site at the downstream end and containing a PGK-neo selection cassette was utilized in the construction of this mutant. This selection cassette was inserted downstream of exon I (also called exon 2, when the first non-coding exon is included in the numbering scheme) of the targeted gene, and another loxP site was inserted upstream of exon III (also called exon 4, when the first non-coding exon is included in the numbering scheme). The PGK-neo selection cassette was removed by Flp-recombinase mediated excision. Exon II is flanked by loxP sites. Cre-mediated recombination removed exon II. (J:266012)

Tumor Data

List all tumor models in MMHCdb carrying Daxx^tm2.1Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Daxx Mutation: 34 strains or lines available

References

• Original: J:266012 Wasylishen AR, et al., Daxx Functions Are p53-Independent In Vivo. Mol Cancer Res. 2018 Oct;16(10):1523-1529
• All: 1 reference(s)