Mdm2^tm5.1Glo
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm5.1Glo
• Name: MDM2 proto-oncogene; targeted mutation 5.1, Guillermina Lozano
• MGI ID: MGI:6256961
• Synonyms: Mdm2^P2
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm5.1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201057
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The critical C and G in the two Trp53 response elements in intron 1 were mutated. These mutations abolish the activity of the P2 promoter. An inverted floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette. (J:201057)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 51 strains or lines available

References

• Original: J:201057 Pant V, et al., The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev. 2013 Sep 1;27(17):1857-67
• All: 3 reference(s)