Del(3Bglap2-Bglap)1Vari
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(3Bglap2-Bglap)1Vari
• Name: deletion, Chr3, Bart Williams; deletion, Chr 3, van Andel Research Institute 1
• MGI ID: MGI:6256960
• Synonyms: Bglap/2^dko, Bglap/2^{p.Pro25fsTer17}
• Gene: Del(3Bglap2-Bglap)1Vari Location: Chr3:88285043-88291771 bp Genetic Position: Chr3, Syntenic

Mutation origin

• Strain of Origin: (C57BL/6 x C3H)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(3Bglap2-Bglap)1Vari involves 3 genes/genome features (Bglap2, Gm6821, Bglap) View all
• Mutation details: CRISPR/Cas9 technology is used to delete exon 2 of Bglap through exon 4 of Bglap2 (6.8 kb). This deletion leaves the first 4 amino acids of exon 2 of Bglap intact followed by a 5bp insertion and a portion of exon 4 of Bglap2. The mutation is predicted to create a reading frame shift after the 25th amino acid and a termination codon 17 residues further downstream. Mature protein is undetectable in homozygous animals. (J:289623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(3Bglap2-Bglap)1Vari Mutation: 1 strain or line available

References

• Original: J:289623 Diegel CR, et al., An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet. 2020 May;16(5):e1008361
• All: 2 reference(s)