Foxo1^em1Guo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxo1^em1Guo
• Name: forkhead box O1; endonuclease-mediated mutation 1, Shaodong Guo
• MGI ID: MGI:6231208
• Synonyms: Foxo1-S273A
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^em1Guo page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Endonuclease-mediated recombination replaced serine 273 with an alanine (TCT to GCT, p.Ser273>Ala). (J:265936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 31 strains or lines available

References

• Original: J:265936 Wu Y, et al., Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis. Diabetes. 2018 Nov;67(11):2167-2182
• All: 4 reference(s)