Tg(Tcra,Tcrb)5Litt
Transgene Detail

Summary

• Symbol: Tg(Tcra,Tcrb)5Litt
• Name: transgene insertion 5, Dan R Littman
• MGI ID: MGI:6220453
• Synonyms: HH7-2tg
• Transgene: Tg(Tcra,Tcrb)5Litt Location: unknown
• Alliance: Tg(Tcra,Tcrb)5Litt page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra,Tcrb)5Litt expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: TCR (Valpha; subset TRAV9-1 and Vbeta; subset TRBV19) sequences recognizing Helicobacter hepaticus-specific epitope QESPRIAAAYTIKGA (E2) were cloned into TCR transgenic vectors pTalpha; and pTbeta that enable transcription under the control of the natural TCRalpha and -beta promoter/enhancer elements. (J:261814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:261814 Xu M, et al., c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. 2018 Feb 15;554(7692):373-377
• All: 4 reference(s)