Mitf^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Mitf^tm1.1Ics
• Name: melanogenesis associated transcription factor; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:6220448
• Synonyms: Mitf^E318K
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting vector was designed to introduce a G to A point mutation at position 952 in exon 9, resulting in a glutamate to lysine change at amino acid 318, and a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:245620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

References

• Original: J:245620 Bonet C, et al., Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression. J Natl Cancer Inst. 2017 Aug 01;109(8)
• All: 1 reference(s)