Bub1b^tm1Tmats
Targeted Allele Detail

Summary

• Symbol: Bub1b^tm1Tmats
• Name: BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Takuya Matsumoto
• MGI ID: MGI:6203660
• Synonyms: BubR1^L
• Gene: Bub1b Location: Chr2:118428692-118472072 bp, + strand Genetic Position: Chr2, 59.4 cM
• Alliance: Bub1b^tm1Tmats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240986
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: An inverse orientation neo cassette was inserted in intron 5 via homologous recombination. This allele produces both a mutant transcript including the neo cassette and a small amount of wild-type transcript. Quantitative rt-PCE indicated that expression in thymi from homozygous mice is 20.9% of that in wild-type controls. (J:240986)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1b Mutation: 60 strains or lines available

References

• Original: J:240986 Kyuragi R, et al., BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):341-7
• All: 2 reference(s)