Gt(ROSA)26Sor^{em1(CAG-HSPB1)Juch}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-HSPB1)Juch}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jun Chen
• MGI ID: MGI:6203656
• Synonyms: HSP27^stop
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-HSPB1)Juch} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-HSPB1)Juch} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HSPB1 (3315)

  Hspb1

  (MGI:96240)

• Mutation details: A construct containing a CAG promoter, a floxed stop cassette, and a human HSPB1 cDNA with an HA tag was inserted via CRISPR/cas9 mediated recombination. (J:240938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:240938 Shi Y, et al., Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1243-E1252
• All: 1 reference(s)