Shc1^em1Kira
Endonuclease-mediated Allele Detail

Summary

• Symbol: Shc1^em1Kira
• Name: src homology 2 domain-containing transforming protein C1; endonuclease-mediated mutation 1, Kaikobad Irani
• MGI ID: MGI:6203127
• Synonyms: P66ShcK81R
• Gene: Shc1 Location: Chr3:89325858-89337336 bp, + strand Genetic Position: Chr3, 39.11 cM
• Alliance: Shc1^em1Kira page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination created an A to G mutation resulting in a lysine to arginine substitution at position 81. This mutation prevents acetylation of this residue. (J:240935)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shc1 Mutation: 66 strains or lines available

References

• Original: J:240935 Kumar S, et al., Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1714-1719
• All: 1 reference(s)